Lab created mutations are created by using radiation or chemicals to alter DNA. Gene splicing does exist that can tailor DNA to suit the company's whims, but at present it is far too expensive for most labs to use (see CRISPR). Most mutations occur randomly and are rarely beneficial, if not fatal (see "Cancer"). Plants can be intentionally cross-bred with other strains to create a beneficial hybrid, which is where every single food we eat came from, so all foods are genetically modified organisms (GMO's). Rice, corn, wheat, barley, and oats are all modified grasses, chickens came from forest birds, domesticated turkeys can't breed naturally due to their enlarged breasts, and so on and so on. Lab created hybrids are no different than those made over the last 12,000+ years of agriculture, other than there is far less trial and error. By the way, the current marketing fad of "GMO Free" is just the latest campaign to separate fools from their money. Before that the fad was "Organic Foods", which was especially silly since organic means containing a carbon chain. Crude oil is organic and you wouldn't want to consume that, would you? Lab created hybrids are no less safe than GMO free. BTW, my personal award for egregiously false or misleading advertising goes to Smirnoff Vodka for saying they are GMO Free. Alcohol is made by distilling fermented sugars, and the bacteria doing the fermenting don't care where the sugars come from.