In ballistics power is speed times bullet weight. Here a light weight 40gr hollow point bullet moving very fast can have the same statistical power as a 80gr soft nose bullet moving much slower (we'll say 1/2 speed to keep the math easy on the brain matter)
Send that fast 40gr into a deer - the hollow cavity instantly fills up with hair + hide, the bullet instantly expands and falls apart with practically all bullet pieces bsorbed in the fat layers and almost no large pieces passing through the fat and into the muscle. You get a heck of wound on the outside of the animal but very little that hit bone or vital organs - it would limp away and die.
Send that 80gr moving half speed into a deer - it will drill though the hair, hide, fat, begin to open in the muscle tissue and continue to break bones and damage vital organs. With decent placement its a one shot clean kill.
Upside to the 40gr HP - one shot clean kill on varmints like fox to wolf. The high speed makes it fly flat and very little drop due to gravity. In a light breeze the wind has little time to push it around but a stiff wind will shove it way, way off course.
Upside to the 80gr soft nose - better choice for deer. The extra weight usually helps buck cross winds which makes it a better choice for target shooting.
You can argue 5.56mm vs 223 all day - the difference is not worth discussing unless you are a hard core NRA highpower rifle competition shooter..... and even then it might not mean much depending on what ammo you are issued.
A smart bunny would worry about proper bullet choice than anything else - all things being equal.
Fact is if I brought 20 to 30 match shooters to the range, and had AR's and Mini-14's chambered and stamped with both chamber styles - might as well toss in a few Wyldes - and I handed them loaded mags of ammo only I knew what it was...…. maybe only one or two experienced shooters would tell the difference. (And I would not be one of them)
Go find something better to worry about. LOL.