It might not seem like sucha bad insult but u never know what kind of insecurities people have. Since youre that worried about what might happen next, definitely talk to her. You will not be able to relax until this situation is resolved, i know because i have anxiety as well.
Make sure to let her know why youre coming to her in the first place, as in, tell her that you noticed her staring at you sadly and were worried. That you didnt mean to hurt her and that your comment wasnt meant in a man way. And that you feel bad for making her think that.
Good luck! Remember to breathe, and dknt think too much of what you say or act like, works wonders!