Gays and lesbians are fine. I think that if they decide to be parents, they should make sure their kids have someone of the sex opposite to their own to interact with.
Transgendered people... I don't hate them, but I sometimes question if we push transition over therapy as a solution too quickly/often. (I realize that I speak from ignorance there.) I don't think they belong in competitive sports, as their abilities will inevitably be between those of cis men and cis women. I do think that gender dismorphia is a mental disorder, but if conversion and treating them as their preferred gender is the best treatment, then that's what should be done. Ultimately, I'll be polite and call them whatever pronouns they like.