I take generic Wellbutrin SR (150 mg) in the morning and at lunch, and Lexapro (10 mg) with dinner, for depression and anxiety. I've been taking that for over two years, and it's working very well for me.
The Wellbutrin SR seems to help me to be more alert and active - and wanting to do things - while the Lexapro makes me more mellow, and it helps me sleep better, too. They are relatively low doses of each medication, which keeps side effects at a minimum. I really can't tell I'm taking any medication at all.
There are a lot of people that take Wellbutrin with their SSRI's, it helps to counteract some of the possible side effects - such as drowsiness, weight gain, and the sexual side effects. It really does make a difference!!