Mother's Little Helper by The Rolling Stones.
"If you take some more of those, you will get an overdose,
No more running for the shelter of your mother's little helper"
It's about antidepressant abuse. Apparently it was bad in the 60's and 70's... though I'm not sure why Ozzy and Mick are singing about not using drugs, Ozzy's more fried than a dinner from KFC, and I'm sure that Mick had his share of tokes and LSD.
You could say that most of Pink Floyd's music is anti-drug in an indirect way. (Crazy, right?) But one of their band members took a wee bit too much LSD, which made him insane, which made him leave the band, which then gave them inspiration for a lot of their hits, and even the whole album Wish You Were Here.
Comfortably Numb is about not taking drugs, as strange as it sounds. When you take drugs, you go totally out of it for a while, and totally out of it isn't a fun place to be. (Trust me, I took too many pain meds once... ugggggh...) One time, one of their leads got sick, and the doctor drugged him up because there was a concert that night and the manager couldn't be losing money, and the lead felt comfortably numb... which isn't a good place to be when you're playing bass.