Best Answer - Chosen by Voters
Getting around NYC is so easy...that you can pretty much stay at any hotel along 5th ave or a few blocks in.
57th and upward blocks (upper east side) ---have high fashion shops---gucci, prada, ralph lauren, etc...
45th is in the mid-town section....you will still find some high end shops around here....but common stores are more popular here...gap, express, j.crew, anthropologie
even further downtown....is the garment district and soho....soho has some wonderful trendy shops plus more common such as urban outfitters, gap.
So what i would do is get the better priced hotel...save money so you can use it for shopping....subways and taxis make it possible to go anywhere really quickly.
Even walking from 45th to 57th is not a big deal...when you are walking and shopping....you can walk 20 blocks easily without realizing how much you walked.