hi, i have been on these tablets for over 4 years and have recently kept lowering the dosage and then eventually coming off them, i was on them for migraine preventatives and also as an antidepressent and as a muscle relaxent, i came off them as was getting more depressed as they made my breath so very bad and over time would stop talking to people no matter what oral hygene things i used, as people would step back as my breath was so bad, doctors and pharmacists just said was a side effect and could do nothing. anyway regards your question i dont think you would be anymore depressed if you came off them than when you went on them, unless you were very depressed when you went on them, in that case cosult your doctor for an alternative.